Medical uses 500mg tablets of Depakote extended-release Valproate or valproic acid is used primarily to treat epilepsy and bipolar disorder. [26] Learn about Depakote (divalproex sodium), which is a drug used to treat certain kinds of seizures and bipolar episodes and prevent migraine headaches. DEPAKOTE® (divalproex sodium) delayed-release tablets and DEPAKOTE® ER (divalproex sodium) extended-release tablets are prescription medicines used: DEPAKOTE ER and DEPAKOTE are also used to prevent migraine headaches. Depakote and Depakote ER are brand-name prescription drugs used to manage manic episodes and certain seizures and to help prevent migraine. It comes as oral tablets and oral capsules, and is. Depakote has been available in the U.S. since 1983, 1 so the healthcare community has had plenty of experience prescribing the 3 Depakote formulations. Their indications are detailed below: Find patient medical information for Divalproex Sodium (Depakote, Depakote ER, Depakote Sprinkles) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and. Depakote is an anticonvulsant for seizures, manic episodes, and migraine prevention. Here are typical Depakote dosages and what to do if you miss your dose or take too much. Depakote ER is a valproate and is indicated for the treatment of acute manic or mixed episodes associated with bipolar disorder, with or without psychotic features. Depakote tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. The tablets are sometimes used together with other seizure medications. Divalproex sodium is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches.